West Ham are out of the FA Cup after suffering a shock 2-nil defeat at League One Wigan in the fourth round.
David Moyes’ side also had Arthur Masuaku sent off in the second-half for spitting.
Masuaku will be punished by the club for his behaviour.
Chris Powell has begun his spell as Southend manager with a dramatic win against Scunthorpe at Roots Hall.
Michael Turner struck the winner in the second minute of stoppage time before the end of the game to finish it 3-2.
The Blues have now moved up to 17th in League One.
In League Two Colchester drew 2-2 with Port Vale.
In the National League South Chelmsford lost 2-1 to Hampton and Richmond, Braintree lost 3-0 to Welling, Concord beat Eastbourne 2-1 and East Thurrock were thrashed 7-2 by Saint Albans.
And in the Isthmian Premier Billericay thrashed Tooting and Mitcham 6-2.