Southend are hoping to make it three wins in a row at home to Barnsley.
The Blues followed up a Johnstone’s Paint Trophy win at Crawley with 3 points at home to Port Vale last week.
Meanwhile Colchester United are hoping to get their first win in October as they go to Wigan.
In League Two, Dagenham & Redbridge entertain Hartlepool.
Braintree are away to Lincoln in the National League while Concord and Chelmsford are in action in the South Division.